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What Are The Symptoms Of Diabetic Kidney Disease?

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Diabetic kidney disease is one of the most common complications in individuals with diabetes and a major contributor to chronic kidney failure!!!

Diabetes can damage the kidneys through various pathways, affecting all structures from the glomerulus and renal blood vessels to the renal tubules and interstitium. Approximately 20%-40% of diabetes patients may develop diabetic kidney disease, and the progression to end-stage renal disease occurs at a rate 14 times faster than other kidney diseases. Therefore, early prevention of diabetes is crucial.

Early Symptoms Of Diabetic Kidney Disease Include

Edema: Edema is a primary manifestation in patients with diabetic kidney disease. In the early stages, most patients do not experience edema. However, some may develop mild edema when plasma protein levels decrease. Significant edema usually appears when 24-hour urine protein exceeds 3 grams.

Proteinuria: Proteinuria is an early sign of diabetic kidney disease. It initially presents as trace amounts of protein in the urine, and it may be intermittent at first but gradually becomes persistent. The presence of proteinuria can predict the progression of diabetic kidney disease.

High Blood Pressure: Almost all cases of diabetic kidney disease are accompanied by high blood pressure. Blood pressure control is closely related to the development of diabetic kidney disease, as hypertension can exacerbate kidney disease, and the two conditions can mutually influence each other.

Anemia: As diabetic kidney disease progresses to renal insufficiency, it can lead to a reduction in the secretion of erythropoietin, resulting in anemia.

Nocturia: Increased nighttime urination is an early symptom of diabetic kidney disease. This occurs because the afferent arterioles of the smallest units of the kidneys, the glomeruli, dilate, while the efferent arterioles, relatively narrowed due to sclerosis, cause an increase in renal blood perfusion pressure. Especially when lying flat at night, renal blood flow increases, leading to the excretion of excess water from the glomeruli. This exceeds the reabsorption capacity of the renal tubules, resulting in increased nighttime urination.

kidney disease

Prevention Of Diabetic Kidney Disease Involves Several Measures

1.Strict Blood Sugar Control

Controlling blood sugar levels can reduce the occurrence and progression of diabetic kidney disease. Fasting blood sugar levels for early and mid-stage diabetic kidney disease patients should be maintained below 7 mmol/L.

Strategies for blood sugar control include strict limitation of calorie intake, adherence to glucose-lowering medications, and avoidance of factors such as emotional stress and infections that can cause blood sugar fluctuations.

2.Limiting Salt Intake

Diabetic individuals should aim for a relatively bland diet, keeping daily salt intake below 6g to protect the kidneys and reduce their workload.

3.Blood Pressure Control

Elevated blood pressure accelerates the progression of diabetic kidney disease. Stable blood pressure control can slow the decline in glomerular filtration rate, reduce urinary albumin excretion, lower the risk of diabetic macrovascular complications, and delay the progression of kidney damage.

The ideal blood pressure level for diabetic patients is generally considered to be 130/80 mmHg. When urinary protein is quantified at more than 1g/24 hours, blood pressure should be controlled below 125/75 mmHg.

4.Regular Exercise

Moderate exercise can increase glucose consumption and improve insulin sensitivity. Aerobic exercises such as jogging and walking are preferable, while intense activities like climbing, fast running, and swimming should be avoided.

It is important to engage in moderate activities, stay adequately hydrated during exercise, adjust clothing as needed, and avoid catching a cold.

5.Regular Checkups

Diabetic kidney disease often presents with few symptoms in the early stages. Therefore, regular urine and kidney function tests are crucial for early detection.

Diabetic patients should undergo periodic examinations to detect the disease early. Early detection and treatment are critical for preventing diabetic kidney disease.

How to Treat Diabetic Kidney Disease

Treatment for diabetic kidney disease involves addressing diabetes and hypertension, incorporating lifestyle changes, exercise, and prescription medications. Controlling blood sugar and high blood pressure is crucial to preventing or delaying kidney dysfunction and other complications.

In the early stages of diabetic kidney disease, the treatment plan may include medications to control various symptoms:

1.High Blood Pressure

Medications such as Angiotensin-Converting Enzyme (ACE) inhibitors and Angiotensin 2 Receptor Blockers (ARBs) are used to treat high blood pressure.

2.High Blood Sugar

Medications help control high blood sugar in diabetic kidney disease patients.

Metformin (Fortamet, Glumetza, etc.) improves insulin sensitivity and reduces glucose production in the liver.

Glucagon-Like Peptide-1 (GLP-1) receptor agonists manage elevated glucose levels by slowing down digestion and stimulating insulin secretion.

Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitors restrict glucose from returning to the bloodstream, increasing glucose excretion in urine.

3.High Cholesterol

Statin medications are used to treat high cholesterol and reduce protein in the urine.

4.Renal Fibrosis

Finerenone (Kerendia) interferes with molecular activities believed to cause inflammation and tissue fibrosis in diabetic kidney disease.

Research indicates that this medication can reduce the risk of kidney function decline, renal failure, heart-related deaths, non-fatal heart attacks, and hospitalization due to heart failure in adults with type 2 diabetes-related chronic kidney disease.

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How to find effective and affordable finerenone tablets

LUCIFINE Finerenone Tablets Is a non-steroidal mineralocorticoid receptor antagonist (MRA) indicated to reduce the risk of sustained eGFR decline end stage kidney disease, cardiovascular death non-fatal myocardial infarction, and hospitalization for hear failure in adult patients with chronic kidney disease(CKD) associated with type 2 diabetes T2D)

If you wish to avoid the symptom, it’s essential to undergo early diagnosis, actively manage diabetes, implement medication, dietary and lifestyle adjustments, and engage in regular monitoring. This approach can help slow down the progression of the disease and reduce the risk of related complications.

It’s widely known that the treatment for type 2 diabetes, RYBELSUS® (semaglutide) tablets, comes with a high cost of up to $995 for 30 tablets. Similarly, the medication for treating diabetic kidney disease, Kerendia finerenone tablets, can be as expensive as $670 for 30 tablets. The exorbitant prices of these medications undoubtedly add to the challenges faced by patients in their daily lives.

Is there an equally effective but more affordable medication available? The answer is LUCIFINE finerenone tablets produced by Lucius Pharmaceuticals. LUCIFINE finerenone tablets are a diabetes kidney disease treatment that has received approval from the Laotian Ministry of Health and is manufactured in Lucius Pharmaceuticals’ GMP factory in Laos, as approved by the U.S. FDA.

LUCIFINE finerenone tablets are not only a legitimately authorized medication but also come at a very affordable price, being only one-third the cost of Kerendia finerenone tablets while delivering the same efficacy.

LUCIFINE finerenone tablets

DKD Care Center serves as the authoritative global distributor for LUCIFINE finerenone tablets, and we possess the necessary authorization certificates from Lucius Pharmaceuticals. The introduction of this new medication comes with significant discounts. If you have been suffering from diabetic kidney disease for an extended period, please don’t hesitate to contact us promptly:

Phone: +852 6993858

Whatsapp: +856 9506 4225



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