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Take Charge of Your Diabetes with Once-Weekly Zafatek Tablets

Zafatek Tablets are a medication used for the treatment of type 2 diabetes mellitus. These tablets contain an active ingredient that inhibits DPP-4 (dipeptidyl peptidase-IV), an enzyme responsible for degrading incretin hormones that help maintain blood glucose levels and stimulate insulin secretion when needed.

Trelagliptin, the active component in Zafatek, is distinct because of its once-weekly dosing schedule, which is relatively infrequent compared to other DPP-4 inhibitors that typically require daily dosing. This can make it more convenient for patients, as it reduces the number of doses they need to remember and take each week.

Are Zafatek Tablets Really Effective for Type 2 Diabetes?

The Pharmaceuticals and Medical Devices Agency (PMDA) has done drug deliberation on Zafatek Tablets. They has concluded that the efficacy of the product in the treatment of type 2 diabetes mellitus has been demonstrated and its safety is acceptable in view of its observed benefits. Safety issues such as hypoglycaemia, skin disorder-related adverse events and hypersensitivity, cardiovascular risk, proarrhythmic risk associated with QT/QTc interval prolongation, gastrointestinal disorder (including pancreatitis), tumor risk, immune system disorders, and infections as well as the safety profile in patients with renal or hepatic impairment and in the elderly, etc. need to be further investigated via post-marketing surveillance.

As a result of its regulatory review, PMDA has concluded that the product may be approved for the indication and the dosage and administration as shown below, with the following conditions.

[Indication] Type 2 diabetes mellitus

[Dosage and administration] The usual adult dosage is 100 mg of trelagliptin orally administered once weekly.

Basic Information of Zafatek Tablets

Product nameZAFATEK® 50mg, ZAFATEK® 100mg
Generic nametrelagliptin succinate
Indicationstype 2 diabetes
Dosage and administrationUsually, for adults, 100 mg of trelagliptin is orally administered once a week
NHI Drug Price50mg: 559.2 yen, 100mg: 1045.1 yen
Zafatek Tablets

Effects of Zafatek Tablets

This medicine inhibits DPP-4, an enzyme degrading incretin hormones that maintain a constant level of blood glucose, to stimulate insulin secretion when blood glucose is elevated and thereby to improve blood glucose control. It is usually used to treat type II diabetes mellitus.

Zafatek Tablets Medication Precautions

The following patients may need to be careful when using this medicine.Be sure to tell your doctor and pharmacist.

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines or foods.

If you have ketosis, diabetic coma or precoma, type 1 diabetes mellitus, severe infection, an injury, renal disorder, pituitary abnormality or adrenal disease.

If you are in a pre- or post-operative status or weakened.

If you do not consume an adequate diet.

If you have been doing vigorous exercise or taking a large amount of alcohol.

If you are pregnant or breastfeeding.

If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Strictly follow the instructions on dietary/exercise therapy.

This medicine may cause hypoglycemia. Pay close attention to operating dangerous machinery, such as working at heights or driving a car. Tell your family members and other people around you that you are taking this medicine.

When hypoglycemia symptoms occur, take an adequate amount of sugar (e.g., sugar, glucose, soft drinks). If you are taking the medicine concomitantly with an alpha-glucosidase inhibitor (medicines which delay absorption of sugar such as voglibose and acarbose), ingest glucose in case of any hypoglycemic symptoms.

Zafatek Tablets 2

How to take Zafatek Tablets

Your dosing schedule prescribed by your doctor is( to be written by a healthcare professional)

In general, for adults, take 2 tablets (100 mg of trelagliptin) at a time, once a week, on a fixed day of the week. The dosage may be reduced according to the degree of renal function in patients with moderate or severer renal dysfunction. Strictly follow the instructions.

If you miss a dose, take the missed dose as soon as possible and then follow your regular weekly dosing schedule. You should never take two doses at one time.

If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.

Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

What are the side effects of zafatek tablets

The most commonly reported adverse reactions include nasopharyngitis, rash and itching. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

・cold sweat, hungry feeling, trembling of limbs [hypoglycemia]

・blister, erosion, red rash [pemphigoid]

・abdominal pain, vomiting [acute pancreatitis]

・constipation, abdominal enlarged feeling, abdominal pain, vomiting [intestinal obstruction]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

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How to get zafatek tablets

To obtain Zafatek tablets, you should follow these steps:

Consult a Healthcare Professional

The first and most important step is to consult a healthcare professional, such as a doctor or an endocrinologist who specializes in diabetes care. They will evaluate your medical condition, including your type 2 diabetes status, and determine whether Zafatek (trelagliptin) is a suitable medication for you.

Medical Evaluation and Prescription

If your doctor decides that Zafatek is appropriate for your treatment, they will write a prescription. This medication should only be used under medical supervision, as it may not be suitable for everyone and could interact with other medications or medical conditions.

Pharmacy Purchase

With the prescription, you can purchase Zafatek tablets from a pharmacy. Depending on your location, it might be available at local pharmacies or through specialized medical distributors.

Insurance and Payment

Check with your insurance provider if the cost of Zafatek is covered under your plan. If not, you might need to pay for it out-of-pocket or explore any patient assistance programs that might be available.

Follow-Up and Monitoring

Regular follow-up appointments with your doctor are crucial while taking Zafatek. Your doctor will monitor your blood sugar levels and overall health to ensure the medication is effective and to adjust the treatment if necessary.

What is zafatek tablets alternatives

Wedica (Trelagliptin)

Wedica is a dipeptidyl peptidase-IV (DPP-4) inhibitor designed for weekly use. It manages blood glucose levels by consistently and selectively inhibiting DPP-4, an enzyme responsible for deactivating glucagon-like peptide-1 and glucagon-dependent insulinotropic polypeptide. These incretin hormones are crucial for regulating blood glucose. The inhibition of DPP-4 promotes insulin secretion based on blood glucose levels, effectively controlling blood glucose. Wedica is conveniently administered orally in tablet form.

Wedica, also known as Trelagliptin, is a medication that belongs to the class of dipeptidyl peptidase-IV (DPP-4) inhibitors. It is used to manage and control blood glucose levels in individuals with type 2 diabetes.

Wedica (Trelagliptin)

Wedica works by selectively inhibiting the DPP-4 enzyme, which would otherwise deactivate incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucagon-dependent insulinotropic polypeptide (GIP). These hormones play a vital role in regulating insulin release in response to blood glucose levels.

By inhibiting DPP-4, Wedica enhances the activity of incretin hormones, leading to increased insulin secretion. This mechanism helps to lower blood glucose levels and improve glycemic control in people with type 2 diabetes. Wedica is typically administered in tablet form for oral use, and its once-weekly dosing schedule provides a convenient option for individuals managing their diabetes.

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Take Charge of Your Diabetes with Once-Weekly Zafatek Tablets

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