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Ozempic semaglutide are best Injectable for type 2 diabetes

Ozempic is a brand name for a medication called semaglutide. It is a prescription medication used to treat type 2 diabetes in adults. Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg is an injectable prescription medicine used:

along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.

to reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease.

ozempic 2

INDICATIONS AND USAGE
OZEMPIC® is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as:
•an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
mellitus .
•to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus
and established cardiovascular disease .
Limitations of Use:
•Has not been studied in patients with a history of pancreatitis. Consider another antidiabetic
therapy .
•Not for treatment of type 1 diabetes mellitus.

DOSAGE AND ADMINISTRATION
•Administer once weekly at any time of day, with or without meals.
•Start at 0.25 mg once weekly. After 4 weeks, increase the dosage to 0.5 mg once weekly.
•If additional glycemic control is needed, increase the dosage to 1 mg once weekly after at least 4 weeks on the 0.5 mg dose .
•If additional glycemic control is needed, increase the dosage to 2 mg once weekly after at least 4 weeks on the 1 mg dosage.
•If a dose is missed administer within 5 days of missed dose.
•Inject subcutaneously in the abdomen, thigh, or upper arm.

OZEMPIC

DOSAGE FORMS AND STRENGTHS
Injection: 2 mg/3 mL (0.68 mg/mL) available in:
•Single-patient-use pen that delivers 0.25 mg or 0.5 mg per injection
Injection: 4 mg/3 mL (1.34 mg/mL) available in:
•Single-patient-use pen that delivers 1 mg per injection
Injection: 8 mg/3 mL (2.68 mg/mL) available in:
•Single-patient-use pen that delivers 2 mg per injection
CONTRAINDICATIONS
•Personal or family history of MTC or in patients with MEN 2.
•Serious hypersensitivity reaction to semaglutide or any of the excipients in OZEMPIC® .
WARNINGS AND PRECAUTIONS
•Pancreatitis: Has been reported in clinical trials. Discontinue promptly if pancreatitis is suspected. Do not restart if pancreatitis is confirmed.
•Diabetic Retinopathy Complications: Has been reported in a clinical trial. Patients with a history
of diabetic retinopathy should be monitored.
•Never share an OZEMPIC® pen between patients, even if the needle is changed.
•Hypoglycemia: Concomitant use with an insulin secretagogue or insulin may increase the risk of hypoglycemia, including severe hypoglycemia. Reducing dose of insulin secretagogue or insulin may be necessary.
•Acute Kidney Injury: Monitor renal function in patients with renal impairment reporting severe
adverse gastrointestinal reactions.
•Hypersensitivity Reactions: Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported. Discontinue OZEMPIC® if suspected and promptly seek medical advice.
•Acute Gallbladder Disease: If cholelithiasis or cholecystitis are suspected, gallbladder studies
are indicated.
ADVERSE REACTIONS
The most common adverse reactions, reported in ≥5% of patients treated with OZEMPIC® are:
nausea, vomiting, diarrhea, abdominal pain and constipation.
DRUG INTERACTIONS
Oral Medications: OZEMPIC® delays gastric emptying. May impact absorption of concomitantly
administered oral medications. Use with caution.
USE IN SPECIFIC POPULATIONS
Females and Males of Reproductive Potential: Discontinue OZEMPIC® in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide.

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How Ozempic Works?

Semaglutide belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone that helps regulate blood sugar levels by stimulating the release of insulin and reducing the amount of glucose produced by the liver. Semaglutide mimics the effects of GLP-1, helping to lower blood sugar levels in people with type 2 diabetes.

Ozempic is typically used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is administered as a once-weekly injection and is available in various doses.

Does Ozempic Semaglutide Really Work In Treating Diabetes?

Ozempic (semaglutide) has been shown to be effective in treating type 2 diabetes. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar levels in several ways.

1.Improved Insulin Production

Ozempic stimulates the pancreas to produce more insulin in response to meals. Insulin is a hormone that helps cells take up glucose from the bloodstream, thus lowering blood sugar levels.

2.Reduced Glucagon Production

It decreases the production of glucagon, another hormone that raises blood sugar levels by promoting the release of glucose from the liver.

3.Slowed Gastric Emptying

Ozempic slows down the emptying of the stomach, which can help reduce the post-meal rise in blood sugar levels.

4.Appetite Regulation

Some people may experience a decrease in appetite, leading to potential weight loss. This can be beneficial for those with type 2 diabetes who are overweight.

Clinical studies have demonstrated the efficacy of Ozempic in improving glycemic control and reducing HbA1c levels (a measure of average blood sugar over time) in people with type 2 diabetes.

Diagnosis and Treatment of Diabetic Kidney Disease

How To Use Ozempic To Treat Diabetes

What you should know Before using OZEMPIC

Before using OZEMPIC®, tell your healthcare provider if you have any other medical conditions, including if you:

• have or have had problems with your pancreas or kidneys.

• have a history of diabetic retinopathy.

• are pregnant or plan to become pregnant. It is not known if OZEMPIC® will harm your unborn baby. You should stop using OZEMPIC® 2 months before you plan to become pregnant. Talk to your healthcare provider about the best way to control your blood sugar if you plan to become pregnant or while you are pregnant.

• are breastfeeding or plan to breastfeed. It is not known if OZEMPIC® passes into your breast milk.

You should talk with your healthcare provider about the best way to feed your baby while using OZEMPIC®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. OZEMPIC® may affect the way some

medicines work and some medicines may affect the way OZEMPIC® works.

Before using OZEMPIC®, talk to your healthcare provider about low blood sugar and

how to manage it. Tell your healthcare provider if you are taking other medicines to treat diabetes, including insulin or sulfonylureas.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

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How Should You Use Ozempic®?

1.Read the Instructions for Use that comes with OZEMPIC®.

2.Use OZEMPIC® exactly as your healthcare provider tells you to.

3.Your healthcare provider should show you how to use OZEMPIC® before you use it for the first time.

• OZEMPIC® is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject OZEMPIC® into a muscle (intramuscularly) or vein (intravenously).

• Use OZEMPIC® 1 time each week, on the same day each week, at any time of the day.

3.You may change the day of the week you use OZEMPIC® as long as your last dose was given 2 or more days before.

4.If you miss a dose of OZEMPIC®, take the missed dose as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and take your next dose on the regularly scheduled day.

5.OZEMPIC® may be taken with or without food.

6.Do not mix insulin and OZEMPIC® together in the same injection.

7.You may give an injection of OZEMPIC® and insulin in the same body area (such as your stomach

area), but not right next to each other.

8.Change (rotate) your injection site with each injection. Do not use the same site for each

injection.

9.Check your blood sugar as your healthcare provider tells you to.

10.Stay on your prescribed diet and exercise program while using OZEMPIC®.

11.Talk to your healthcare provider about how to prevent, recognize and manage low blood sugar

(hypoglycemia), high blood sugar (hyperglycemia), and problems you have because of your diabetes.

12.Your healthcare provider will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1C.

13.Do not share your OZEMPIC® pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

14.Your dose of OZEMPIC® and other diabetes medicines may need to change because of:

• change in level of physical activity or exercise, weight gain or loss, increased stress, illness,

change in diet, fever, trauma, infection, surgery or because of other medicines you take.

• If you take too much OZEMPIC®, call your healthcare provider or go to the nearest hospital emergency room right away.

ozempic 3

The Correct Way To Use Ozempic

INSTRUCTIONS FOR USE OZEMPIC® [oh-ZEM-pick] (semaglutide) injection, for subcutaneous use 0.25 mg or 0.5 mg doses (pen delivers doses in 0.25 mg or 0.5 mg increments only)

OZEMPIC® pen and NovoFine® Plus needle (example):

ozempic pen
A

Step 1
Prepare your pen with a new needle

1.Wash your hands with soap and water.

2.Check the name and colored label of your pen, to make sure that it contains OZEMPIC®.

3.Pull off the pen cap.

This is especially important if you take more than 1 type of medicine.

B

Check that the
OZEMPIC® medicine
in your pen is clear
and colorless.
Look through the pen
window. If OZEMPIC®
looks cloudy or contains
particles, do not use the
pen.

C

Take a new needle,
and tear off the paper tab.
Do not attach a new
needle to your pen until
you are ready to give your
injection.

D

Push the needle
straight onto the pen.
Turn until it is on
tight.

E

The needle is covered
by 2 caps. You must
remove both caps.
If you forget to remove
both caps, you will not
inject any medicine.

Pull off the outer needle cap. Do not throw it away.

F

Pull off the inner
needle cap and throw
it away. A drop of
OZEMPIC® may appear
at the needle tip. This is
normal, but you must still
check the OZEMPIC®
flow if you use a new pen
for the first time.

Always use a new needle for each injection. This will reduce the risk of contamination, infection, leakage of OZEMPIC®, and blocked needles leading to the wrong dose. Do not reuse or share your needles with other people. You may give other people a serious infection, or get a serious infection from them. Never use a bent or damaged needle.

Step 2.
First Time Use for Each New Pen: Check the OZEMPIC®
flow

1.Check the OZEMPIC®
flow before the first
injection with each
new pen only.
If your OZEMPIC® pen is
already in use, go to Step
3 “Select your dose”.

2.Turn the dose selector
until the dose counter
shows the flow check
symbol.

H

1.Hold the pen with the
needle pointing up.
Press and hold in the
dose button until the
dose counter shows 0.
The 0 must line up with
the dose pointer.
A drop of OZEMPIC® will
appear at the needle tip.

2.If no drop appears,
repeat Step 2 above as
shown in Figure G and
Figure H up to 6 times.
If there is still no drop,
change the needle and
repeat Step 2 as shown
in Figure G and Figure H
1 more time.
Do not use the pen if
a drop of OZEMPIC® still
does not appear.

Always make sure that a drop appears at the needle tip before you use a new pen for the first time. This makes sure that OZEMPIC® flows.
If no drop appears, you will not inject any OZEMPIC®, even though the dose counter may move. This may mean that there is a blocked or damaged needle. A small drop may remain at the needle tip, but it will not be injected. Only check the OZEMPIC® flow before your first injection with each new pen.

I

Step 3.
Select your dose

Turn the dose selector
until the dose counter
stops and shows your
dose (0.25 mg or
0.5 mg).
The dashed line in the
dose counter will
guide you to your dose.
Make sure you know the
dose of OZEMPIC® you
should use. If you select
the wrong dose, you can
turn the dose selector
forward or backwards to
the correct dose.

Always use the dose counter and the dose pointer to see how many mg you select.

You will hear a “click” every time you turn the dose selector. Do not set the dose by counting the number of clicks you hear.

Only doses of 0.25 mg or 0.5 mg can be selected with the dose selector. The selected dose must line up exactly with the dose pointer to make sure that you get a correct dose. The dose selector changes the dose. Only the dose counter and dose pointer will show how many mg you select for each dose.

You can select 0.25 mg or 0.5 mg for each dose. When your pen contains less than 0.5 or 0.25 mg, the dose counter stops before 0.5 mg or 0.25 mg is shown. The dose selector clicks differently when turned forward or backward. Do not count the pen clicks.

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J

How much OZEMPIC® is left?

To see how much OZEMPIC® is left in your pen, use the dose
counter:
Turn the dose selector until the dose counter
stops.

If it shows 0.5, at least 0.5 mg is left in your pen. If the dose counter stops before 0.5 mg, there is not enough OZEMPIC® left for a full dose of 0.5 mg.

If it shows 0.25, at least 0.25 mg is left in your pen. If the dose counter stops before 0.25 mg, there is not enough OZEMPIC® left for a full dose of 0.25 mg.
If there is not enough OZEMPIC® left in your pen for a full dose, do not use it. Use a new OZEMPIC® pen.

K

Step 4.
Inject your dose

Choose your injection
site and wipe the skin
with an alcohol swab.
Let the injection site dry
before you inject your
dose (See Figure K).

L

Insert the needle
into your skin as your
healthcare provider has
shown you.

Make sure you can
see the dose counter.
Do not cover it with your
fingers. This could stop
the injection.

M

Press and hold down the dose button until the dose counter shows 0.
The 0 must line up with the dose pointer. You may then hear or feel a click.
Continue pressing the dose button while keeping the needle in your skin.

N

Count 6 seconds while keeping the dose button pressed.

If the needle is removed earlier, you may see a stream of OZEMPIC® coming from the needle tip. If this happens, the full dose will not be delivered.

O

Remove the needle from your skin. You can then release the dose button.
If blood appears at the injection site, press lightly with a gauze pad or cotton ball. Do not rub the area.

Always watch the dose counter to make sure you have injected your complete dose. Hold the dose button down until the dose counter shows 0.

How to identify a blocked or damaged needle?
• If 0 does not appear in the dose counter after continuously pressing the dose button, you may have used a blocked or damaged needle.
• If this happens you have not received any OZEMPIC® even though the dose counter has moved from the original dose that you have set.

How to handle a blocked needle?
Change the needle as described in Step 5, and repeat all steps starting with Step 1: “Prepare your pen with a new needle”.

Never touch the dose counter when you inject. This can stop the injection.
You may see a drop of OZEMPIC® at the needle tip after injecting. This is normal and does not affect your dose.

P

Step 5.
After your injection

Carefully remove the
needle from the pen.
Do not put the needle
caps back on the needle
to avoid needle sticks.

Q

Place the needle in a sharps disposal container right away to reduce the risk of needle sticks. See “Disposing of used OZEMPIC® pens and needles” below for more information about how to dispose of used pens and needles the right way.

R

Put the pen cap on
your pen after each use to
protect OZEMPIC® from
light.

S

If you do not have a sharps disposal container, follow a 1-handed needle recapping method.
Carefully slip the needle into the outer needle cap. Dispose of the needle in a sharps disposal container as soon as possible.

Never try to put the inner needle cap back on the needle. You may stick yourself with the needle. Always remove the needle from your pen. This will reduce the risk of contamination, infection, leakage of OZEMPIC®, and blocked needles leading to the wrong dose. If the needle is blocked, you will not inject any OZEMPIC®. Always dispose of the needle after each injection.

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What Are The Possible Side Effects Of Ozempic?

Ozempic (semaglutide) is generally well-tolerated, but like any medication, it can cause side effects in some people. Common side effects of Ozempic include:

Nausea: Some people may experience nausea, especially when they first start taking Ozempic. This side effect often improves over time.

Vomiting: Vomiting is another gastrointestinal side effect that may occur.

Diarrhea: Some individuals may experience diarrhea, but this side effect is usually temporary.

Constipation: On the other hand, some people may experience constipation.

Abdominal Pain: Pain or discomfort in the abdominal area can occur.

Headache: Headaches are a reported side effect for some individuals.

It’s important to note that not everyone will experience these side effects, and many people tolerate Ozempic well. Additionally, side effects often diminish over time as the body adjusts to the medication.

Serious side effects are rare, but they can occur. These may include pancreatitis (inflammation of the pancreas), allergic reactions, kidney problems, and changes in vision. Seek medical attention if you experience severe abdominal pain, persistent vomiting, or signs of an allergic reaction (such as rash, itching, swelling, severe dizziness, or difficulty breathing).

How much does Ozempic cost?

The price of Ozempic (semaglutide) can vary depending on several factors, including: Insurance coverage, Prescribed dosage, Pharmacy, Injection pen.

On average, Ozempic costs around $892.06 per month without insurance. With insurance, it can cost as little as $25 for a monthly supply.

In certain situations, it is possible to obtain Ozempic without charge. Novo Nordisk provides a patient assistance program that offers Ozempic at no expense. To qualify, individuals must be U.S. citizens or legal residents with a total household income equal to or below 400% of the federal poverty line. Additionally, they should not be covered by insurance, Medicare, or any other federal, state, or government programs such as Medicaid or VA benefits.

Alternatives to Ozempic

Ozempic Semaglutide belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. Some of  Ozempic alternatives are as best as Ozempic.

Semaglutide Tablets

Semaglutide is a medication used to treat type 2 diabetes, and it belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. Here’s how semaglutide works in treating diabetes:

Mimicking GLP-1 Hormone: GLP-1 is a natural hormone produced by the intestines in response to food intake. It plays a crucial role in regulating blood sugar levels. Semaglutide mimics the action of GLP-1.

Stimulating Insulin Release: One of the primary actions of semaglutide is to stimulate the release of insulin from the pancreas. Insulin is a hormone that helps cells in the body absorb glucose (sugar) from the bloodstream, thus lowering blood sugar levels.

Inhibiting Glucagon: Semaglutide also reduces the production of glucagon, another hormone released by the pancreas. Glucagon normally signals the liver to release glucose into the bloodstream. By inhibiting glucagon, semaglutide helps decrease the amount of glucose produced by the liver.

Slowing Gastric Emptying: Semaglutide slows down the rate at which food is emptied from the stomach into the small intestine. This delay in gastric emptying helps to control the rise in blood sugar levels after meals.

Promoting Weight Loss: GLP-1 receptor agonists, including semaglutide, can contribute to weight loss. They may reduce appetite and promote a feeling of fullness, leading to decreased food intake and, consequently, weight loss.

Improving Beta Cell Function: Semaglutide may also have a positive impact on the function and survival of beta cells in the pancreas. Beta cells are responsible for producing insulin, and their proper function is essential for maintaining blood sugar control.

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References:https://www.novo-pi.com/ozempic.pdf#guide