Skip to content

6 Symptoms Indicating You Might Have Diabetic Kidney Disease

6 Symptoms Indicating You Might Have Diabetic Kidney Disease

Diabetic kidney disease is one of the most severe microvascular complications of diabetes. According to relevant data, globally, every 10 seconds, two people are diagnosed with diabetes. Every year, 3.8 million people worldwide die from diabetes-related diseases, and every 10 seconds, one person dies from diabetes-related diseases. It is estimated that by 2030, the global population affected by diabetes will reach as high as 366 million. Kidney damage is one of the more serious complications. Without effective treatment, it can progress to kidney failure, ultimately requiring lifelong dialysis.

kidney

The early stages of diabetic kidney disease are not as easily traceable as diabetes itself. Generally, there are no obvious signs in the early phase, making it easy to overlook. So, how can diabetic kidney disease be detected early? Patients should pay attention to the following symptoms!

Typical symptoms of diabetic kidney disease

Diabetic Kidney Disease Symptom 1: Edema

After developing diabetes, especially when blood sugar control is poor, it’s more likely to trigger kidney disease. Once kidney disease is induced, symptoms become more apparent, such as the presence of edema. Edema is when you feel that your entire body is swollen, similar to bloating. This is one of the symptoms of diabetic kidney disease.

Diabetic Kidney Disease Symptom 2: Lower Back Pain

Diabetic kidney disease can manifest with lower back pain. The pain is typically situated higher in the back, often around the angle just below the ribcage. It can occur on one side or both sides and is usually persistent. The reasons for lower back pain in diabetic kidney disease include:

1. Sensory nerves are distributed around the renal capsule, ureter, and renal pelvis, so irritation or increased tension in these areas can lead to visceral neuropathic pain.

2. Kidney damage affecting nerves can also result in lower back pain.

3. Due to the loss of normal regulatory function in the kidneys, there may be ongoing lower back pain in clinical cases.

If middle-aged or elderly individuals experience unexplained bone fractures, frequent lower back pain, bone pain, or osteoporosis, and no abnormalities are found through orthopedic examinations, it’s essential to consider a kidney evaluation.

Lower Back Pain

Diabetic Kidney Disease Symptom 3: Frequent Urination and Urgency

Typically, a classic symptom of diabetes is polyuria, polydipsia, polyphagia, and weight loss. In diabetes, polyuria not only means an increase in the frequency of urination but also a significant increase in the volume of urine. In a 24-hour period, there can be more than twenty urinations, totaling 2 to 3 liters, or even as much as 10 liters. The urine may appear foamy and cloudy. Polyuria is a result of elevated blood sugar levels exceeding normal values, leading to an increased excretion of sugar in the urine, which results in both increased frequency and volume of urination.

Diabetic Kidney Disease Symptom 4: Unstable Blood Pressure

When there are unusual fluctuations in blood pressure or initial hypertension issues, it’s important to check for kidney disease. Especially in young and middle-aged individuals, if unexplained high blood pressure occurs, it’s essential to assess kidney function.

Diabetic Kidney Disease Symptom 5: Changes in Urine

1. Presence of Foam in Urine

 In a healthy individual, there should be no foam when urinating, and any bubbles should quickly dissipate. If the foam in the urine doesn’t dissipate and persists, it indicates the presence of urinary protein and uncontrolled blood sugar. Prolonged high blood sugar levels in diabetes can affect kidney function, leading to the excretion of urinary protein. When urinary tension increases, it can result in noticeable foaming during urination.

2.Increased Stickiness

If the urine feels sticky when excreted, it indicates high glucose content in the urine. All diabetes patients have elevated blood sugar levels, and even if their internal environment is stable, excess glucose is excreted through the urine, leading to the presence of urinary sugar. Most ants are attracted to sweet substances. If you notice many ants after urination, it’s a sign that blood sugar is not well controlled.

3.Unusual Odor in Urine

Urine from diabetic patients contains various compounds, and when these mix, they can create chemical reactions, resulting in a noticeable odor. Additionally, diabetic patients have higher blood sugar levels, and to maintain balance, the body eliminates excess sugar through urination, leading to an increased frequency of urination.

Urine

Once the above symptoms appear, even if blood sugar is well-controlled at that time, it’s important to consider the possibility of early diabetic kidney disease and promptly seek medical evaluation. Diabetic kidney disease, as a significant health concern, warrants widespread attention. Traditional medication can only provide partial protection against the development and progression of diabetic kidney disease to some extent. Therefore, it’s essential to select the appropriate treatment based on the individual patient’s circumstances to manage diabetic kidney disease effectively.

Effective Medicine treatment of Diabetic Kidney Disease

LUCIFINE Finerenone Tablets Is a non-steroidal mineralocorticoid receptor antagonist (MRA) indicated to reduce the risk of sustained eGFR decline end stage kidney disease, cardiovascular death non-fatal myocardial infarction, and hospitalization for hear failure in adult patients with chronic kidney disease(CKD) associated with type 2 diabetes T2D)

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of a drug and may not reflect the rates observed in practice.

The safety of LUCIFINE was evaluated in 2 randomized, double-blind, placebo-controlled, multicenter pivotal phase 3 studies, FIDELIO-DKD and FIGARO-DKDin which a total of 6510 patients were treated with 10 or 20 mg once daily over a mean duration of 2.2 and 2.9 years, respectively.

Overall, serious adverse events occurred in 32% of patients receiving LUCIFINE and in 34% of patients receiving placebo in the FIDELIO-DKD study: the findings were similar in the FIGARODKD study. Permanent discontinuations due to adverse events also occurred in a similar proportion of patients in the two studies (6-7% of patients receiving LUCIFINE and in 5-6% of patients receiving placebo).

The most frequently reported (≥10%)adverse reaction in both studies was hyperkalemia [see Warnings and Precautions(5.1)]. Hospitalization due to Hyperkalemia for the LUCIFINE was 0.9% vs 0.2% in the placebo group across both studies. Hyperkalemia led to permanent discontinuation of treatment in 1.7% receiving LUCIFINE versus 0.6% of patients receiving placebo across both studies.

LUCIFINE is a CYP3A4 substrate. Concomitant use with a strong CYP3A4 inhibitor increases Finerenone exposure, which may increase the risk of LUCIFINE adverse reactions. Concomitant Use of LUCIFINE with strong CYP3A4 inhibitors is contraindicated see Contraindications (4) Avoid concomitant intake of grapefruit or grapefruit juice.

Moderate and Weak CYP3A4 Inhibitors LUCIFINE is a CYP3A4 substrate. Concomitant use with a moderate or weak CYP3A4 inhibitor increases Finerenone exposure, which may increase the risk of LUCIFINE adverse reactions. Monitor serum potassium during drug initiation or dosage adjustment of either LUCIFINE or the moderate or weak CYP3A4 inhibitor, and adjust LUCIFINE dosage as appropriate [(see Dosing and Administration (2.3) and Drug interaction (7 .2)]. Strong and Moderate CYP3A4 inducers.

LUCIFINE is a CYP3A4 substrate. Concomitant use of LUCIFINE with a strong or moderate CYP3A4 inducer decreases Finerenone exposure. which may reduce the efficacy of LUCIFINE. Avoid concomitant use of LUCIFINE with strong or moderate CYP3A4 inducers.

LUCIFINE Finerenone Tablets
LUCIFINE Finerenone Tablets

Why choose LUCIFINE Finerenone Tablets

It’s widely known that the treatment for type 2 diabetes, RYBELSUS® (semaglutide) tablets, comes with a high cost of up to $995 for 30 tablets. Similarly, the medication for treating diabetic kidney disease, Kerendia finerenone tablets, can be as expensive as $670 for 30 tablets. The exorbitant prices of these medications undoubtedly add to the challenges faced by patients in their daily lives.

Is there an equally effective but more affordable medication available? The answer is LUCIFINE finerenone tablets produced by Lucius Pharmaceuticals. LUCIFINE finerenone tablets are a diabetes kidney disease treatment that has received approval from the Laotian Ministry of Health and is manufactured in Lucius Pharmaceuticals’ GMP factory in Laos, as approved by the U.S. FDA.

LUCIFINE finerenone tablets are not only a legitimately authorized medication but also come at a very affordable price, being only one-third the cost of Kerendia finerenone tablets while delivering the same efficacy.

DKD Care Center serves as the authoritative global distributor for LUCIFINE finerenone tablets, and we possess the necessary authorization certificates from Lucius Pharmaceuticals. The introduction of this new medication comes with significant discounts. If you have been suffering from diabetic kidney disease for an extended period, please don’t hesitate to contact us promptly:

Phone: +852 6993858

Whatsapp: +856 2099383722

Email: service@finerenonediabeticnephropathy.com

Website: finerenonediabeticnephropathy.com

Leave a Reply

Your email address will not be published. Required fields are marked *